α-fetoprotein-binding toxins and teratogens against cancer
نویسندگان
چکیده
منابع مشابه
Persistent α-Fetoprotein Elevation in Healthy Adults and Mutational Analysis of α-Fetoprotein Promoter, Enhancer, and Silencer Regions
Background/Aims α-Fetoprotein (AFP) is normally <10 ng/mL in adults without malignancy or liver regeneration. However, hereditary or nonhereditary persistence of AFP in healthy adults may be encountered in clinical practice. This study describes four cases of persistent AFP elevation in healthy adults and investigates mutations in key transcription regulatory regions of the AFP gene as potentia...
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BACKGROUND Heat shock severely affects sperm production (spermatogenesis) and results in a rapid loss of haploid germ cells, or in other words, sperm formation (spermiogenesis) is inhibited. However, the mechanisms behind the effects of heat shock on spermatogenesis are obscure. METHODOLOGY/PRINCIPAL FINDINGS To identify the inhibitory factor of spermiogenesis, experimental cryptorchid (EC) m...
متن کاملTeratogens and Their Effects
A congenital malformation is an anatomical or structural abnormality present at birth. Congenital malformations may be caused by genetic factors or environmental insults or a combination of the two that occur during prenatal development. Most common congenital malformations demonstrate multifactorial inheritance with a threshold effect and are determined by a combination of genetic and environm...
متن کاملProtection against Shiga Toxins
Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface. To intoxicate cells efficiently, the toxin A-moiety has to be cleaved by furin and transported retrogradely to the Golgi apparatus and to the endoplasmic reticulum. The enzymatically active part of the A-moiety is then translocated to the cytosol, w...
متن کاملBinding modes and functional surface of anti-mammalian scorpion α-toxins to sodium channels.
Scorpion α-toxins bind to the voltage-sensing domains of voltage-gated sodium (Na(V)) channels and interfere with the inactivation mechanisms. The functional surface of α-toxins has been shown to contain an NC-domain consisting of the five-residue turn (positions 8-12) and the C-terminus (positions 56-64) and a core-domain centered on the residue 18. The NC- and core-domains are interconnected ...
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ژورنال
عنوان ژورنال: Therapeutic Delivery
سال: 2019
ISSN: 2041-5990,2041-6008
DOI: 10.4155/tde-2018-0068